I removed Darwinports from my OS X mailserver because it was affecting my perl builds since my perl builds were going to /opt/local instead of their normal location. This was really messing up all the perl program dependencies for Spamassassin. All I had to do to remove Darwinports was to remove the /opt/ directory and the /etc/opt/ directory. After that, all the Perl builds and pointers went to the correct location.
On another note, Spamassassin has been working very well between FuzzyOCR, the network checks and the Bayes database.